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1. Irish Flu
A particularly unpleasant hangover.
"Last night was great, but I have the worst case of the irish flu today."
by Melissa Jul 10, 2004 add a video
2. Irish flu
A hangover, usually involving whiskey; may be mild or severe
"I’ve still got a touch of the Irish flu."

"The Irish flu?"

"Also known as a hangover."

(from "A Nose for Murder" by Lee Charles Kelley
3. Irish Flu
The ailment one suffers on March 18th after properlyly celebrating St. Patrick's Day. Anyone of Irish descent may also use the term to denote a hangover on any day of the year.
Seamus: Ugh, I was out drinking Guinness until the wee hours. I think I'll call in with the Irish Flu today.
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