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1.
Any one of those thousands of "friends" you may have made on any number of social media sites (Instagram, Facebook,......and yes even Myspace) that you have never met or will probably never meet, but claim as a buddy because they "liked" your pictures and or "followed" you.
Steve: "So my friend Dave Chappelle and I were chatting today"

Joe: "Fool you know damn well you don't know Dave Chappelle!"

Steve: "Yeah I do! We are good friends"

Joe: "Yeah right! "Inter-Friends" maybe! LOSER!
by The_Penguin_Gazette January 05, 2013
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2.
An interfriend is a friend you meet on the Internet.
Noob OMGZORZ, MY INTERFRIENDZ ARE LEIK ONLINEZORZ!!!111!!!11 YAYZORZ!!1!!1111!111one!!11

Me Get a life you fucknut.
by drumSTICKS January 05, 2008
1 1