When you're in very serious trouble. More trouble than when someone says that they're "in the shit". A clean version of this is "In the DS".
Example #1: Fuck! We're in the damn shit for about $80,000 bucks!

Example #2: Fuuka just found out her boyfriend totally cheated on her with Yukari. Oooh, he's in the damn shit now...
by MasterMenos August 13, 2012
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A women that looks good as hell from the back, but has an ugly ass face. When you see her Body you say Daaaamn!, but when you see her face you say Oh Shit!
That chick was a Damn Shit.
by Big Daddy ACE October 1, 2005
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a sign of distress or annoyance... can sometimes be used as an exclamation...
Boss: Guess what! You have to work a double shift tomorrow! HAHAHAHA!
Worker: Oh Damn Shit!

or...

Friend A: Look at the booty on that one!
Friend B: I know, man... damn shit!
by Frickin' Jerms March 25, 2007
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Equivalent to damn straight, but typically reserved to the “money money” members. Much like the n-word is to the urban brothers
That guys sucks at rocket league. Damn-shit!
by MoneySupremeLeader June 11, 2022
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What you say if something strange or surprising happens.
When Charlie hit his toe, he screamed out "Damn!Shit!Fuck!"
by ChristmasLite March 17, 2009
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When The Gabbie Show gets criticized harshly and has had learned too much info.
*Gabby walks to two friends fighting*
Gabby: Guys, Stop Fighting!
Friend 1: Why don't you stop eating Gabby?
Friend 2: Yeah! That's why your friend cheated on you!
Gabby: Okay! Damn! Shit!
by Turkish Superhuman July 23, 2016
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