ISU
Also known as Illinois State University and also commonly known as "I Screwed Up" because upon the rejection letter to University of Illinois-Urbana Champaign(UIUC), the individual realizes that he/she did in fact screw up in high school and also screwed up the rest of their entire lives because they will now be obliged to attend a far less impressive, selective, and inferior University and will spend the next 4-7 years trying to graduate in order to obtain an average degree.
Kid: "Mom, I got rejected from UIUC..."

Mom: "So what's that mean?"

Kid: "Looks like I'm gonna havta go to ISU"

Mom: "You really screwed up, didn't you?"

Kid: "I sure did..."
by UofIbiiiitches March 28, 2011

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Top Definition
ISU
Iowa State University, a school located in Ames, Iowa.
ISU's mascot is the Cyclone.
by Isi Oamen June 28, 2004

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ISU
independent study unit , for school purposes
Man did u start your ISU, it's worth 15% of your mark and it's due tomorrow!
by darkxsoldier January 07, 2009

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ISU
When referring to colleges, a joke is commonly made using the acronym ISU, meaning "I Screwed Up"
Mark could have done so much better, but instead he went to ISU.
by Steve Koivisto March 06, 2008

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isu
Idaho State University. The Bengals.
ISU's ________ team sucks this year like they do every year.
by addicted March 01, 2005

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An ancient Jewish martial art. Thought to be developed by the mysterious Ninjews of the Northeastern United States, but heavily practiced in Boca Raton, FL.
That shiksa waitress spilled soup all over my lap, so I threatened the manager with some I-Su, and I ended up getting dinner on the house, with free dessert thrown in.
by Armed & Hammered July 28, 2006

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It means Jesus, in Croatian
Jesus is the same as Isus.
by Croat January 01, 2005

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ISU
Illinois State University in Bloomington-Normal Illinois.
ISU are the Redbirds.
by Redbirds rock September 27, 2004

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