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2. I.S.
Information Systems
High School computer geeks usually go on to lucrative careers in I.S. departments.
by Tom Cumbow Jan 23, 2004 add a video
1. i.s.
independent study
i am part of i.s.
by rick Jun 8, 2003 add a video
3. i.s.
inverse smile
i.s.
by t. sheather Nov 3, 2002 add a video
4. I.S.
The term for a man's rather large thang "Italian sausage"
"Yoo girl u want to taste some of this italian sausage?"
by Nigga Dust May 22, 2005 add a video
5. I.S.
Short for Itis Spot. A designated chill spot for a group of friends to chill and get over the itis (short for niggeritis)
Pronounced "is" not i.s.
"Yo dude, the itis is hittin' me quicktime, let's hit up I.S."

Friend 1: "Yo, ima go home and get some sleep before soccer dude."
Friend 2: "Nah, let's just hit up I.S. for a quick minute."
6. i.s.
I stupid...me kno nothing
I.S. didn't ya kno that?
by Tanya Dec 31, 2003 add a video
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