When, quite literally, a person is pissed off so bad that they cannot mentally, emotionally, or physically (teehee @ pun) take it anymore.
K': You're such a fuck up. I think you fail at life. You're the biggest loser I've ever met. Your IQ is the equivalent to an apple.

Random Girl: ZOMG I CAN'T TAKE IT ANYMORE! STOP INSULTING ME BEFORE I SNIP YOUR BABY CARROT OFF!
by Iconoklastic~ February 24, 2010
exclamtion used by those caught up in something unbearable.
After three hours of listening to the chemistry teacher's lecture on the nature of farts, a student cried out, "I can't take it anymore!"
by Al Gebra January 05, 2010

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