1. The process which occurs when Humanity reaches it's evolutionary peak, and evolves back into a primordial ooze, starting the evolutionary process all over again.
2. An evolutionary Theory in which the entire world is the product of the imagination of a boy who does not realize what he really is.
3. The end of the world.
4. To reduce humanity and civilization to a single hive mentality, by stripping them of their individualities and combining all hearts, souls and minds into one coherent existence.
The instigation of Human Instrumentality would bring about peace and harmony, but it would make us lose everything that makes us unique. But we would all agree and be happy.