The inability to get laid.
Condoleezza Rice is so horizontally challenged, it's not funny.
by Assweepay September 23, 2005
An overweight person.
I'm sick of being horizontally challenged, it's time to get a gym membership around here!
by Mr Natural June 07, 2007
A large fat fuck that is literally challenged to walk. He usually wobbles as he creates massive earthquakes upon his massive kankles. Usually a horizontally challenged person whether it be a guy or girl smells like shit because they do not wash under their rolls or titties.
Rosie O'donnell is horizontally challenged.
by MrBlik October 30, 2009