1. Another term for homie, but more personal and often used amongst friends of the highest value.

2. A slice of homie. You have a group of homies, and homeslice is used to address just one of them.
Kristy: "Hey Peta, wanna go skateboarding?"

Peta: "Sure, homeslice."
by Kristy deSM November 08, 2011
noun. A real buddy or paisan.
You know, you've been my number one home slice for about ten years now. Thanks.
by Kaworu June 30, 2004
home, referring to the ever so popular phrases including the following: home dawg, home nizzle, homie, homes..etc. and slice, referring to the freaking shiz niz (referring to the best of something) of the best of something

"What it do, homeslice?"

"OH, it do, dawg."
by Lt. Boom City April 04, 2009
Is used in addition to bisnatch, referring to a friend or someone who is relatively nice in order to get their attention.
Yo homeslice! Pay attention!
by causte March 08, 2005
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