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1. Hoe muffin
When someone is really sweet, but a hoe, and you don't want to call them a hoe in a mean way.
Jessica, that's the 4th hook up you had in 2 days.. you're such a hoe muffin!
2. hoe muffin
a word used as a pet name.
or a fanny bandit aka faggot.
jenny, your such a hoe muffin LETS FUCK!
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