A reference to the lack of understanding what exactly a "Ho" is saying, it can be used as an interjection such as when Susie is bitching about money and you are enjoying your money, you pretend to be listening and randomly shout "Howhat" it can also be in the form of a question, when a "Ho" questions a higher authority, It's a shortened form of (Ho What the hell you doing). It can also be a way to pick out potential "Ho's" try shouting it in a room of females and see who says something first.
1) Interjection: I can't believe those broke ass niggas took my Tv, and the Waffle Hizouse is holding my last check, and My sister's Ho tendencies are costing me a fortune and-" said Susie
"-HoWhat" you retort
(end of conversation)
2) What do you want for dinner Andre?
What do you want for dinner?
3)Can I borrow some money?
(Slaps Ho for thinking of asking)
4) HoWhat? I'm coming.