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1.
HSD
an acronym, commonly used on the Internet, meaning "holy shit, dude", derived from the infamous South Park feature film, 'South Park: Bigger, Longer, & Uncut' quote - Kyle Broflovski
Mr. Garrison: What did you say?!
Eric Cartman: Oh, I'm sorry, I'm sorry. What I said was: How would you like to SUCK MY BALLS, Mr. Garrison?
Kyle Broflovski: Holy shit, dude(HSD)...
by BenJAMSTER July 10, 2008
 
2.
HSD
Acronym for 'hardcore street drugs'. Usually means heroin, crack, meth, etc.
Yo, let me get some of those HSDs!
by slsanity August 24, 2013
 
3.
Holy Snapping Duck Shit - an exclamation of total surprise.
Holy snapping duck shit! When I posted hsds I didn't mean Hardcore Satan Death Sex
by JMannus May 02, 2011
 
4.
HSD
High Sex Drive.
Normally owned by males who masturbate to much. Can end in death of their girlfriend.
Unless the girl has it too...
Boy: Come here, *Grunts* Ooooh more.
Girl: Fuck stop that hurts!
Boy: You like it!
Girl: Stop! You have HSD...
by GeeHSDx September 07, 2008