Top Definition
When a man urinates into a girl's eye as a way to relieve itching, redness and cure Pink Eye.
Jessica had a very serious case of Pink Eye, and was in desperate need of Guysine so Jordan and Lance peed in her eye and she went on her way to work. Cured!
1 more definition
When a man shoots a Woman in the eye with his jizz.
Damn, I gave the bitch a shot of guysine
by Gruv April 11, 2006

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