Top Definition
When a man urinates into a girl's eye as a way to relieve itching, redness and cure Pink Eye.
Jessica had a very serious case of Pink Eye, and was in desperate need of Guysine so Jordan and Lance peed in her eye and she went on her way to work. Cured!
When a man shoots a Woman in the eye with his jizz.
Damn, I gave the bitch a shot of guysine
by Gruv April 11, 2006
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