Top Definition
When someone plays guitar hero so much that they get blisters all over their hands that resemble herpes.
Guy 1:Yo Bro I got Five stars on Jordan on expert.
Guy 2:Ew Bro have Guitar Hero Herpes from trying so hard. How long did it take you to beat it?
Guy 1: Five months
Guy 2: Yo im not your Bro anymore your just a faggot
by JaHizzle August 19, 2007

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