Top Definition
Guitar Hero hand syndrome is what happens when you play guitar hero for a very long time (5+ years) and whenever a guitar solo or any music that you can follow along to you start playing air guitar and it really does not make you look cool it makes you look more like a poser
Person 1: Man i think i been playing Guitar Hero for to long i think i have Guitar Hero Hand Syndrome *starts playing air guitar*

Person 2: Dude stop playing that silly game and start playing real guitar
by MidnightStar Sparks September 18, 2011

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