Top Definition
A potent, mutated form of testosterone found typically in New Jersey males which results in mutations such as silly spiked hair, orange skin, and lips puckering. Sufferers of guidosterone also tend to abuse anabolic steroids and wear clothes too small for them.
Whoa, look at that Guido over there with the bottle of grey goose, he's all hopped up on guidosterone. What a douche.
by Jmanus June 04, 2010

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