Usually pronounced as "Guidooooneee", emphasis on the "o". Guidone is an Italian name, a nickname for it is Guido, even though the name Guidone is a good enough name and doesnt need a nickname. A person from the Guidone descent is the cool kid at school, hott, everyone wants to be their friend cuz they are where the party's at. The essence of cool.
Yo, Guidone you comin tonight?
by 832457 June 24, 2006