It is used to express indignation, usually towards stupidity, incompetence, or both.
It can be used in response to something that is unwelcome.
An easy to use acronymn when dealing with moronic incompetents in the online world.
Use when not particularly interrested in thinking up a some new glib whitticism.
2. Who the fuck cares, online noob bashing is a stupid way to spend your time using the acroynm GTFO.
3. John was so tired of his bitch, when Mark asked how the move was, he pointed to his T-shirt that said GTFO.
The actual meaning behind this acronym is beside the obvious (which is to get the fuck out). It is best used in a situation not unlike that of one where a girl or maybe a friend that the rents hate to leave the house immediately, because they are coming home.
Your buddy: No, that was your pillow case. And you slept on it anyway.
You: GTFO!! Is that why my hair is so sticky?!