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The act of inserting an intoxicating pill into ones rectum for pleasure or science
"I swallowed my pills, Sean Griffined his, he says he gets higher that way"
by mynameismudd August 21, 2012
a term for getting jizzed on, or getting screwed, in a way that sounds appropriate so you can say it anywhere.
Your girlfriend is sucking that guy's dick over there, you just got Griffined!
by Peter Griffin March 21, 2005