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2.
To totally fuck somebody over, to the extent that it completely ruins the person's day, year, or even life. Used especially when someone is left hanging.
so we were about to get into this club last night, then paul went grady little on us and threw up on the bouncer, and we got our asses whipped.
by Colin G. October 29, 2007
 
1.
n. Worst baseball coach ever.
see also: Moron, Idiot, Retard, Fag
1. Grady Little is the biggest retard in the history of Sports Management.
2. Can Grady Little coach a team? No because he is a moron
by Dan October 17, 2003