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1.
It means cover your fucking mouth
Guy 1: God bless you

Guy 2: Sorry I'm an Atheist
by FinaLWoot. September 22, 2008
 
2.
When someone says "god Bless You" You are obligated to smack yourself in the face before five seconds passes. This "game" originated in New Jersey by the name of a fellow named Christopher Wheeler and another by the name of Matt Boyle. This game has been active for about 5 or six years now and is popular in the Tri-State area (NJ, NY, CT, PA and just expanded to TN)
Someone says "god bless you bitch"

You Smack yourself in the face before they pelt you in the face.
by Christopher J. Wheeler October 04, 2006
 
3.
people's way of starting a conversation
"god bless you, oh, and by the way, what's your name"
by etlkj November 14, 2003
 
4.
After cumming in a person's mouth, you hit them in the back of the head or make them laugh and it will come out their nose. Also see the Dragon's Breath.
Rob gave Sarah a God Bless You and a kleenex.
by Tyler Stebbins July 20, 2006