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1.
A slightly archaic euphemism for "hitting the family jewels." First used in the NFL in 1986 in an NFL game where the Jets defense tackled the Bills quarterback and starting hammering the qb right in the baby maker.

Second usage was during the Maryland vs North Carolina State football game where Number 69 of NC was penalized for doing the same thing.

In straight terms: punching someone in the balls.
*after the flag was thrown*
Referee: "Personal Foul, Number 69, offense. He was "giving him the business". Fifteen yard penalty, first down!"

*two friends talking*
Guy A: "Man, I would like to beat that bastard in. He makes me sick to the stomach."
Guy B: "Make sure you give him business while you're at it."
by Dom Sage October 07, 2013