1. A person native to Ghana. A play on words mixing "Ghana" and "gonorrhea".
2. A promiscuous person who has or is likely to have contracted gonorrhea.
Conan: "Hey that bartender Katie is pretty smokin. I'm gonna try to get her number."
Winters: "Dude you don't wanna hit that. I heard she hooks up with like ten guys a week. She's a total Ghanarrhean.