The guilt one feels when coming down from a multiple day speed/meth/ghack binge. Sorrow filled hopelessness in a scattered meth mind. When you realize that you are seriously out of control and it's affecting your life and others.
"I feel like I'm going nowhere with my life". I'm so fucking up on the ghack, '! "Come on dude relax, you just got a bad case of ghackers guilt'.