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1.
This is from one of those dumbass "Above the Influence" commercials where the kids are sitting in a diner and one says to another "hey we about to go get twisted, you in?". The definition of "twisted" is never revealed, which confuses the audience because, frankly, nobody in history has ever said they are getting fucking twisted.
Stereotypical Black kid 1: Aye Mane we bout to go get twisted, you in?

Stereotypical Black kid 2: What the fuck? Are you hitting one me? I told yo gay ass I don't go that way! Shit I'm bout to get high and say fuck yall niggas. You can go twist ya dicks together for all I care!
by yourmomlovesmyjohnson09 December 05, 2010
 
2.
Getting intoxicated. Smoking, drinking, pill popping...
I get twisted every Friday.
by FatBoyMag.com March 27, 2009