There comes a time in Resident Evil 4, when the big fella with a gatling gun pops outta nowhere and begins shooting things like theres no tomorrow. There is a place where he hops onto a rooftop, which basically means your screwed.
"Omgwtfbbq, you forgot about the gatler on the roof!"
"The gatler on the rooftop is around the corner, get ready to run for your fucking life. Or just pull out the handcannon."