A night in which folks get together for the ultimate purpose of getting laid (i.e. engage in sex with someone). Game night is more than a game, it is a philosphy and a state of mind. Game Night isn't hanging out with people and just having fun; it's about going on a mission.
Ben, Paul, Will and Jack got together and went downtown Friday night. As they realized it was Game Night, these guys wasted no time going about mugging down on some hoes.