GUI
Stands for "Genius Under the Influence". It is a term used for individuals who come up with fantastic ideas when abusing some kind of substance, or for those students who actually do quality schoolwork while completely fucked up.
Student # 1: "I can't believe I got an 'A' on that paper. I was so high when I did it I couldn't even remember what I wrote about."

Student # 2: "WTF. You should totally be charged with a GUI."
by GreenParrot713 October 26, 2009
Photos & Videos
Top Definition
GUI
Graphical User Interface.

A visual display of files, programs, and program directories designed to make it easier for a person to use a computer.
Microsoft Windows has an easy-to use GUI.
by AYB April 04, 2003
the way a dyslexic person would spell "guys"
person one: lol u guis crack me up!

jenny and sue: lmao! did he just say guis!?!?
by meadowlark3000 May 11, 2009
Get Up In , when seeing one of your friends creepin on a person you yell it as a code word as to not let the person whos getting creeped on know that you just told you friend to have sex with that person
at the bar or at school "dam josh is really creepin on that chick, G.U.I. bro!! "
by suga ehans April 03, 2011
GUI
The noise you make when something enters your asshole
Bill: GUI, GUI, GUI, yea, shove that loaf of bread in my asshole more Steve
Steve: Ok Bill. Your turn.
Bill: alrighty:
Steve: GUI GUI GU- OUCH! That really hurt bill
by GUIMACHINE123 September 16, 2013
The act of drinking a large amount of alcohol, and gobbling like a turkey.
Jim drank a whole bottle of Dack Janiels and gobbled loudly and waddled around like a turkey for well over ten minutes. Then soon after, a police officer tasered him, cuffed him, and took him into custody. He's going to do six months community service for his G.U.I. That poor bastard.
by CHEEZITJEzUS July 19, 2013
dutch for cool, awesome

(tof, gaaf, biekwauzend)
In dutch you would say:
'Die website is guis !'

means: 'That website is awesome'
by Kozie July 10, 2008
Gui
A handsome hunk of a man, who is gay
Girl 1: Look it´s Gui
Girl 2: I WANNA TOUCH HIM
Guy: Back off he is MINE!!
by SandHobgoblin November 20, 2014
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