gui
A way for total n00bs to use a computer.
Jim: The Mac OS X gui is cool!!!!

Tim: You're a n00b!
by The Keasbey Knight April 19, 2008

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GUI
pronounced as Jooey: Sometimes you just cant decide wether you'd rather play some good old fashioned COD or get a nice blow from your girlfriend. Why not settle for both. This is where the GUI come in... Gaming under the influence. Now you can play with both sticks at the same time.

This the ultimate gaming experience. So get your girl, get your XBox and get under the influence.
Tommy was ignoring his girlfriend Laura, being he was in the middle of level 27 on Nazi Zombies. In order to resolve this conflict Laura proposed a GUI, which allowed him to keep his tip wet and destroy some zombies all at the same time.
by Lulu&AmDam October 25, 2010

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the way a dyslexic person would spell "guys"
person one: lol u guis crack me up!

jenny and sue: lmao! did he just say guis!?!?
by meadowlark3000 May 11, 2009

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gui
A Graphical User Interface. The addition of GUI's to most modern operating systems has revolutionised the populous' ability access pornographic material, and contributed greatly to the happiness of the single geek/male population.
Oh dude, this pussy looks so hot in HD, thanks to my GUI!
by Axman6 January 25, 2008

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Generosity Under the Influence

When one gives away more than they usually would because of excessive drinking or the like
"My wife gave me a G.U.I. after I donated WAY too much money at that charity dinner last night. I don't even remember being there."
by DarvidBerring December 02, 2009

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GUI
Stands for "Genius Under the Influence". It is a term used for individuals who come up with fantastic ideas when abusing some kind of substance, or for those students who actually do quality schoolwork while completely fucked up.
Student # 1: "I can't believe I got an 'A' on that paper. I was so high when I did it I couldn't even remember what I wrote about."

Student # 2: "WTF. You should totally be charged with a GUI."
by GreenParrot713 October 26, 2009

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gui
lingo coming from milltown,nj. how to say "guy" the proper way. (gu-i)
hey thats the gui that was tlking to that gui with that gui over there by that gui
by xxalaska101xx January 25, 2011

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