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16.
GUI
GUIs (Graphical User Interface) were created as an effort to make computers appealing to non-computer-savy, or "ignorant" masses.

Windows users are inherently GUI users. This of course also implies that they do not know ASM or unix, or they would use something else.

Knowing better, computer-savy people only use text terminals, which they often call consoles. This implies that they use telnet to browse HTTP web sites as opposed to a GUI-cripled browser. When they need to look at pictures of their significant other, they do so using the aalib library to view them as ASCII-art.
Accessing your favorite dictionary the real man's way:

% telnet urbandictionary.com 80
Host: urbandictionary.com\r\n
GET / HTTP/1.1\r\n
\r\n\r\n

Turning into a helpless zombie like the majority of clueless computer users submitting to GUI e-slavery:

C:> win.exe
<wait for the BSOD>
by Ananda Panderoza December 07, 2007
 
1.
GUI
Graphical User Interface.

A visual display of files, programs, and program directories designed to make it easier for a person to use a computer.
Microsoft Windows has an easy-to use GUI.
by AYB April 04, 2003
 
2.
the way a dyslexic person would spell "guys"
person one: lol u guis crack me up!

jenny and sue: lmao! did he just say guis!?!?
by meadowlark3000 May 11, 2009
 
3.
Get Up In , when seeing one of your friends creepin on a person you yell it as a code word as to not let the person whos getting creeped on know that you just told you friend to have sex with that person
at the bar or at school "dam josh is really creepin on that chick, G.U.I. bro!! "
by suga ehans April 03, 2011
 
4.
GUI
The noise you make when something enters your asshole
Bill: GUI, GUI, GUI, yea, shove that loaf of bread in my asshole more Steve
Steve: Ok Bill. Your turn.
Bill: alrighty:
Steve: GUI GUI GU- OUCH! That really hurt bill
by GUIMACHINE123 September 16, 2013
 
5.
The act of drinking a large amount of alcohol, and gobbling like a turkey.
Jim drank a whole bottle of Dack Janiels and gobbled loudly and waddled around like a turkey for well over ten minutes. Then soon after, a police officer tasered him, cuffed him, and took him into custody. He's going to do six months community service for his G.U.I. That poor bastard.
by CHEEZITJEzUS July 19, 2013
 
6.
dutch for cool, awesome

(tof, gaaf, biekwauzend)
In dutch you would say:
'Die website is guis !'

means: 'That website is awesome'
by Kozie July 10, 2008
 
7.
gui
A Graphical User Interface. The addition of GUI's to most modern operating systems has revolutionised the populous' ability access pornographic material, and contributed greatly to the happiness of the single geek/male population.
Oh dude, this pussy looks so hot in HD, thanks to my GUI!
by Axman6 January 25, 2008