gui
a synonym for pussy,vagina, vaginal cavity, shit like that, can be used by anyone( but only sounds good in a black mans mouth). this version of the word was founded in technology class:

can also be a sub for bitch, broad, redbone, bobblehead, shit like that.
teacher: alright class GUI: what does it mean.
nigga: yo dats wat i got from ya momz:
other nigga: yea well ya ass better be happy dat ya moms GUI is nasty ass hell,
by yung chizzle May 25, 2007
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Top Definition
GUI
Graphical User Interface.

A visual display of files, programs, and program directories designed to make it easier for a person to use a computer.
Microsoft Windows has an easy-to use GUI.
by AYB April 04, 2003
Gui
A mythological creature, often useless and bad at everything it does.
Man, you're such a gui ...
by Nubita June 29, 2016
the way a dyslexic person would spell "guys"
person one: lol u guis crack me up!

jenny and sue: lmao! did he just say guis!?!?
by meadowlark3000 May 11, 2009
GUI
The noise you make when something enters your asshole
Bill: GUI, GUI, GUI, yea, shove that loaf of bread in my asshole more Steve
Steve: Ok Bill. Your turn.
Bill: alrighty:
Steve: GUI GUI GU- OUCH! That really hurt bill
by GUIMACHINE123 September 16, 2013
Get Up In , when seeing one of your friends creepin on a person you yell it as a code word as to not let the person whos getting creeped on know that you just told you friend to have sex with that person
at the bar or at school "dam josh is really creepin on that chick, G.U.I. bro!! "
by suga ehans April 03, 2011
The act of drinking a large amount of alcohol, and gobbling like a turkey.
Jim drank a whole bottle of Dack Janiels and gobbled loudly and waddled around like a turkey for well over ten minutes. Then soon after, a police officer tasered him, cuffed him, and took him into custody. He's going to do six months community service for his G.U.I. That poor bastard.
by CHEEZITJEzUS July 19, 2013
Gui
A handsome hunk of a man, who is gay
Girl 1: Look it´s Gui
Girl 2: I WANNA TOUCH HIM
Guy: Back off he is MINE!!
by SandHobgoblin November 20, 2014
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