1. to go puke, usually with reference to the "Grand Old Party" a.k.a. Republicans
2. if someone republican has said something stupid, or made you angry, you might say ewwww i'm gonna GOPuke now...
3. can also express distaste for/be a parody of Project GOPink
republican girlie: gay marriage and abortion should be illegal.
democratic/libertarian girlie: excuse me while i GOPuke