Top Definition
(n.) The feeling of X-TREME pain and discomfort accompanied by the discoloration of the knuckles and pinky caused by playing Guitar Hero II for over 5 hours straight.
Teacher: d00d, wtf happened to your hand lolz? It'z all malformed and Y3110|/\|!!!11!!one!

Billy's Friend: He's got MAJOR GH Syndrome.

Billy: I was trying to play Freebird on expert for like, 10 hours. Oh god... I can't feel my pinky >_<!
by Garrett Funk June 04, 2007

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