1. Derived from the word fuck. Meaning to "go fuck yourself you piece of shit"
2. A combination of the words fuck,shit,you. Its origin can be traced back to San Joaquin valley,CA. Most likely Stockton circa early 90's.
3. Known to the English language as a word so insulting its victims usually die of shock.
Person 1:Hey you over there!
Person 2: Oh my God!!! (dies of shock)