Definition #2: A company, organization, or any other type of workplace that breeds stupid/shitty people, workflows, practices or other types of fuckery on a continuous basis. In this definition, working in a fucktropolis will lead to fuckophrenia.
"I hate this fucktropolis. The nearest store is 5 miles away, there's nowhere to go and nothing to do but fuck your own cousin."
Example for Definition #2: "I hate working at this fucktropolis! Nobody knows how the fuck to do their jobs, then everybody expects me to clean up their shit. They don't pay me enough for this bullshit!"