Top Definition
To perform a slight error that unwittingly caused horrible, catastrophic level events

reference to: the widely-believed myth that AIDS began after someone fucked a monkey, caught the disease and then spread it through mankind.
A: "so I was writing a dirty email to my girl and accidentally sent it to my boss, her husband found it on her phone, thought she was cheating, and killed her and himself, now the company is folding and 400 people are without work and since this is a private hospital it's leaving 1000 patients without care....."

B: "dude, you fucked the monkey"
by Dyrk Diggler March 15, 2011

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