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1.
To mess something up so bad that it is impossible to fix or take back.
Dude you dropped my bong! You fucked it. Now how are we going to smoke?
by L1$$4 November 17, 2011
 
2.
*blazed* When you do something abnormally bad but because you're blazed you've come to the realisation that there's nothing you can do.

Then you've fucked it.
blazed bad bad man realisation Fucked it - When you kick your monitor off and it smashes and normally you know you'd be like "I'll have to buy a new one :(",
by TehEchidna October 10, 2009