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2.
used as !:exclamation:!;
being overly fucked (usually by the same person);
as in Deep Shit;
cant pull the wool over mine eyes.
Fuck me twice!!! i aint into that shit.
by Dominic Rosario November 10, 2006
 
1.
idiom; used to express feelings of extreme frustration, exasperation, annoyance, surprise, resignation, or disappointment
"Yyyyeah, V, I'm gonna need you to work another eight hours while your 'sick' coworker goes out partying and whoring herself."

"Oh, fuck me twice!"

*

"Fuck me twice, I can't believe that 'Signs' sucked so bad."
by pentacookie December 04, 2007