A phrase said in a similar manner and context to "Fuck My Life" except used when ones wife/girlfriend is the source of grief
Bill: Hey Mike I got some tickets to the Rangers game tonight, you in?
Mike: Oh hell yeah buddy, just let me run it by my old lady
Wife: Michael you promised me that you would watch the third Harry Potter movie with me tonight, you know how scared I get
Mike: ugh Fuck My Wife, sorry Bill I can't come
by Kim4321 March 31, 2010
an exclaimation of frustration or horror.
She just shit on my dick?! FUCK MY WIFE!
by CHELApants November 13, 2007

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