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1.
A phrase said in a similar manner and context to "Fuck My Life" except used when ones wife/girlfriend is the source of grief
Bill: Hey Mike I got some tickets to the Rangers game tonight, you in?
Mike: Oh hell yeah buddy, just let me run it by my old lady
Wife: Michael you promised me that you would watch the third Harry Potter movie with me tonight, you know how scared I get
Mike: ugh Fuck My Wife, sorry Bill I can't come
by Kim4321 March 31, 2010
22 10
 
2.
an exclaimation of frustration or horror.
She just shit on my dick?! FUCK MY WIFE!
by CHELApants November 13, 2007
22 20