A term only understood by people within Buffalo, NY who have had to tolerate bombardments of advertisements from Billy Fucillo. His catch phrase (screaming "HUGE") has made him infamous, therefore condoning "Fucillo huge" as something larger than what would normally be considered huge. It's usually asked after the statement of something being huge, jokingly.
Tony: "The Bills just had a huge loss."
Brian: "Fucillo huge?"
Tony: "(laughter) yeah ... but seriously you're a douche."