Top Definition
Affliction of a persons ability to form relationships with members of the opposite sex. Usually involves a person being perpetually placed in the friend zone due to his or her lack of appropriate game or ability to communicate his intentions with a female or male.
John: Hey man whats going on with Jamie?
Geoff: Man it sucks. She says im just her friend!
John: Dang man again? You got Friends Zone Syndrome Hard.
by TLPeeze December 08, 2008

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