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1.
The feeling one gets on a friday night when attempting or contemplating to have a quiet weekend, often in correlation to drugs, withdrawal.
Eg.1 Fuck, the girlfriend wants me to lay off the coke this weekend... hopefully the friday blues wont get the better of me.

Eg.2 I've got 3 assignments and a mid term due next week, i best be gettin some weed cause im gonna have the friday blues bad.
by wombatSTEW August 20, 2008