One of Buffalo Bill's first victims in Silence of the Lambs. She is described as "a great big fat person." The term is now generally used to be describe someone who is both overweight and unlucky. Repeated mentions by Jimmy Norton of The Opie and Anthony Show drive the popularity of the term.
"It seems old Frederica Bimmel over there is having some difficulty loading her couch into the van. We should help before she breaks an arm."