When you get raped by Doug Fister. Since being fisted destroys that region, being fistered is also destructive. If you have ever been fisted or seen someone fisted, you understand what I mean. He who has been Fistered has been utterly defeated, such as the 2011 New York Yankees.
The Yankees thought they would advance to the ALCS without Verlander on the bump for the Tigers, but they were Fistered by Dougie Fresh.