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1.
Taken from the saying "It ain't over until the fat lady sings," commonly attributed to ex-Yankee ballplayer Yogi Berra.

Presumably, the "fat lady" in question is a stereotyped opera singer, replete in Wagnerian Rhinemaden garb. Ironically enough, the "fat lady" was usually singing the United States National Anthem, the traditional way to START a baseball game.
Sure, we're behind by 300 points. But it ain't over until the fat lady sings.
by Packy April 11, 2004
 
2.
A pair of 8's in poker.
My fat ladies beat your treys! Muahahahahahahah!
by rhaps0dy August 04, 2004