Top Definition
Ed Zachary Disease is when your face looks exactly like your ass, meaning you are extremely ugly.
"Ed Zachary Disease is when your face rook Ed Zachary rike your ass." - Dr. Chang of China
by -Brad- May 17, 2006

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When someone's face looks Ed Zachary like their ass.
Once, an ugly girl that was making a pass at me described that she wasn't feeling very well.
I said, "Well, if I were a doctor, I think I might diagnose you with Ed Zachary Disease."
She asked what it was and I said, "When your face look Ed Zachary like yo ass."
She wasn't amused.
by Roy L'Ourtiere July 18, 2006

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When a person's breath is SO BAD that their mouth smells "Ed Zachary" like their asshole.
If you do not brush your teeth you are going to have Ed Zachary Disease, and no babe will want to kiss you.
by makomark13 October 27, 2008

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The Urban Dictionary Mug

Lotsa space for your liquids.

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The Urban Dictionary Mug

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The Urban Dictionary Mug

One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.

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The Urban Dictionary T-Shirt

Soft and offensive. Just like you.

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The Urban Dictionary T-Shirt

Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).

Buy the t-shirt