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1.
To fight, usually fist fight. Probably from John 'the Duke' Wayne movies where he would always end up fighting with someone.
You want to teach him a lesson, duke it out.
by BobLoblaws October 13, 2006
 
2.
the act of pooping or taking a dump.
boy1: hey were where you last night at the party?
boy2: i had to duke it out.
boy1: oh.
by thunder_storm996 July 10, 2008