look up any word, like the eiffel tower:
 
3.
A stupid person; a dufus; moron
Zoe, you're such a dufo.
by Carissa November 23, 2003
 
1.
Dufo is a word for people thath do amazing things for their freinds or family.
mr.X : "Hey **** can you help me with a quest?"
Dufo : "Sure"
mr.X : "Omg your awsume thx"
by dufo_plus_knifer_4_eva July 23, 2008
 
2.
Drugged Up F*** Off
"Hey man, How's it going?"
"DUFO"
"Lame/Cool"
by JunkieInMotion February 06, 2010