by Doo Doo Delpra June 25, 2011
by Moe June 17, 2006
To get your ass kicked REALLY badly. If you got "duffed", you didn't just get punched in the face, hit the floor and kicked once or twice hard... you got hit in the face, hit the ground, then got hit in the face several more times, possibly had your head bashed into the cement, got kicked in the ears, neck, kidneys and various other soft spots on your body.
"Yung, that nigga D-Set laid up in the hospital. He smoked up that whole QP he was fronted by main man and got duffed."
by Krill Awareness March 7, 2006
Hillary received a beautiful engagement ring. Right after, she was caught on camera duffing her boyfriend on the barcalounger.
by Opeth1429 February 26, 2010
An acronym for Designated Ugly Friend. Every hot girl has a DUF simply to make her look that much hotter. This strategy also works for average looking girls.
by Ryan June 18, 2004
by Mcduffing April 10, 2019
by Scarlett_the_Slayer November 8, 2018