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1.
Drapetomania is a term that derived in the slave days and was used to describe the "disease" in which the symptoms were "a slave that was addicted to attempting escape or escaping slavery..."

Cure: cut off their toes.
None needed.
by Chris Johnson May 11, 2004
 
2.
The overwhelming urge to run away.
I'm sick of this city, Drapetomania is taking me over.
by snickel May 14, 2011